Ontology highlight
ABSTRACT:
SUBMITTER: Quadeer AA
PROVIDER: S-EPMC6502829 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Quadeer Ahmed A AA Louie Raymond H Y RHY McKay Matthew R MR
Nature communications 20190506 1
Isolation of broadly neutralizing human monoclonal antibodies (HmAbs) targeting the E2 glycoprotein of Hepatitis C virus (HCV) has sparked hope for effective vaccine development. Nonetheless, escape mutations have been reported. Ideally, a potent vaccine should elicit HmAbs that target regions of E2 that are most difficult to escape. Here, aimed at addressing this challenge, we develop a predictive in-silico evolutionary model for E2 that identifies one such region, a specific antigenic domain, ...[more]