Ontology highlight
ABSTRACT:
SUBMITTER: Pozarickij A
PROVIDER: S-EPMC6502837 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190506
A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations. Currently however, the extent of gene-environment or gene-gene interactions in myopia is unknown. We tested the hypothesis that refractive error-associated variants exhibit effect size heterogeneity, a hallmark feature of genetic interactions. O ...[more]