Ontology highlight
ABSTRACT:
SUBMITTER: Ricciuti B
PROVIDER: S-EPMC6503327 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ricciuti Biagio B Genova Carlo C Crinò Lucio L Libra Massimo M Leonardi Giulia Costanza GC
OncoTargets and therapy 20190430
The development of deep-sequencing methods is now unveiling a new landscape of previously undetected gene fusion across different tumor types. Chromosomal translocation involving the <i>NTRK</i> gene family occur across a wide range of cancers in both children and adults. Preclinical studies have demonstrated that chimeric proteins encoded by <i>NTRK</i> rearrangements have oncogenic properties and drive constitutive expression and ligand-independent activation. Larotrectinib (ARRY470, LOXO101, ...[more]