Ontology highlight
ABSTRACT:
SUBMITTER: Skachokova Z
PROVIDER: S-EPMC6503541 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Skachokova Zhiva Z Martinisi Alfonso A Flach Martin M Sprenger Frederik F Naegelin Yvonne Y Steiner-Monard Viviane V Sollberger Marc M Monsch Andreas U AU Goedert Michel M Tolnay Markus M Winkler David T DT
Acta neuropathologica communications 20190507 1
Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer's disease (AD). Tau derived from AD patients' brains induces tau aggregation in a prion-like manner when injected into susceptible mouse models.Here we investigated whether cerebrospinal fluid (CSF) collected from patients diagnosed with probable AD or mild cognitive impairment (MCI) likely due to AD harbors a prion-like tau seeding potential. CSF was injected intrahippocampally into young P301S tau transgenic mice. CSF ...[more]