Ontology highlight
ABSTRACT:
SUBMITTER: Story S
PROVIDER: S-EPMC6503653 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20181114
The development of new ligands that have comparable or enhanced therapeutic efficacy relative to current drugs is vital to the health of the global community in the short and long term. One strategy to accomplish this goal is to functionalize sites on current antimicrobials to enhance specificity and affinity while abating resistance mechanisms of infectious organisms. Herein, we report the synthesis of a series of pyrene-neomycin B (PYR-NEO) conjugates, their binding affinity to A-site RNA targ ...[more]