Ontology highlight
ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC7269645 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Dai Zhefu Z Zhang Xiao-Nan XN Nasertorabi Fariborz F Cheng Qinqin Q Li Jiawei J Katz Benjamin B BB Smbatyan Goar G Pei Hua H Louie Stan G SG Lenz Heinz-Josef HJ Stevens Raymond C RC Zhang Yong Y
Science advances 20200603 23
Most of the current antibody-drug conjugates (ADCs) in clinic are heterogeneous mixtures. To produce homogeneous ADCs, established procedures often require multiple steps or long reaction times. The introduced mutations or foreign sequences may cause high immunogenicity. Here, we explore a new concept of transforming CD38 enzymatic activity into a facile approach for generating site-specific ADCs. This was achieved through coupling bifunctional antibody-CD38 fusion proteins with designer dinucle ...[more]