Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Zsolt D
PROVIDER: S-EPMC6503733 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Perez-Zsolt Daniel D Cantero-Pérez Jon J Erkizia Itziar I Benet Susana S Pino Maria M Serra-Peinado Carla C Hernández-Gallego Alba A Castellví Josep J Tapia Gustavo G Arnau-Saz Vicent V Garrido Julio J Tarrats Antoni A Buzón Maria J MJ Martinez-Picado Javier J Izquierdo-Useros Nuria N Genescà Meritxell M
Frontiers in immunology 20190430
Antigen presenting cells from the cervical mucosa are thought to amplify incoming HIV-1 and spread infection systemically without being productively infected. Yet, the molecular mechanism at the cervical mucosa underlying this viral transmission pathway remains unknown. Here we identified a subset of HLA-DR<sup>+</sup> CD14<sup>+</sup> CD11c<sup>+</sup> cervical DCs at the lamina propria of the ectocervix and the endocervix that expressed the type-I interferon inducible lectin Siglec-1 (CD169), ...[more]