Ontology highlight
ABSTRACT:
SUBMITTER: Lee MY
PROVIDER: S-EPMC6503971 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Lee Monica Y MY Gamez-Mendez Ana A Zhang Jiasheng J Zhuang Zhenwu Z Vinyard David J DJ Kraehling Jan J Velazquez Heino H Brudvig Gary W GW Kyriakides Themis R TR Simons Michael M Sessa William C WC
Arteriosclerosis, thrombosis, and vascular biology 20180215 4
<h4>Objective</h4>The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises the possibility of cell-type-dependent Akt1-driven actions, thereby necessitating tissue-specific characterization.<h4>Approach and results</h4>Herein, we used an inducible, endothelial-specific Akt1-deleted adult mouse model (Akt1iECKO) to ...[more]