Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC6503988 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhu Sijun S Chen Rui R Soba Peter P Jan Yuh-Nung YN
Development (Cambridge, England) 20190417 8
Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using <i>Drosophila</i> class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show tha ...[more]