Ontology highlight
ABSTRACT:
SUBMITTER: Morotz GM
PROVIDER: S-EPMC6505310 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Mórotz Gábor M GM Glennon Elizabeth B EB Gomez-Suaga Patricia P Lau Dawn H W DHW Robinson Eleanor D ED Sedlák Éva É Vagnoni Alessio A Noble Wendy W Miller Christopher C J CCJ
Acta neuropathologica communications 20190508 1
Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here we show that LMTK2 also interacts with kinesin-1 light chains (KLC1/2). Binding to KLC1/2 involves a C-terminal tryptophan/aspartate (WD) motif in LMTK2 and the tetratricopeptide repeat (TPR) domains in KLC1/2, and this interaction facilitates a ...[more]