Ontology highlight
ABSTRACT:
SUBMITTER: Taylor-Whiteley TR
PROVIDER: S-EPMC6505482 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Taylor-Whiteley Teresa R TR Le Maitre Christine L CL Duce James A JA Dalton Caroline F CF Smith David P DP
Disease models & mechanisms 20190409 4
Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated Lewy bodies from endogenous wild-type α-synuclein, translationally regulated under its own promoter in human cell culture models, requires costly and time-consuming protocols. Here, we demonstrate that fully differentiated human SH-SY5Y neuroblastoma c ...[more]