Ontology highlight
ABSTRACT:
SUBMITTER: Greenwald WW
PROVIDER: S-EPMC6505525 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Greenwald William W WW Chiou Joshua J Yan Jian J Qiu Yunjiang Y Dai Ning N Wang Allen A Nariai Naoki N Aylward Anthony A Han Jee Yun JY Kadakia Nikita N Regue Laura L Okino Mei-Lin ML Drees Frauke F Kramer Dana D Vinckier Nicholas N Minichiello Liliana L Gorkin David D Avruch Joseph J Frazer Kelly A KA Sander Maike M Ren Bing B Gaulton Kyle J KJ
Nature communications 20190507 1
Genetic variants affecting pancreatic islet enhancers are central to T2D risk, but the gene targets of islet enhancer activity are largely unknown. We generate a high-resolution map of islet chromatin loops using Hi-C assays in three islet samples and use loops to annotate target genes of islet enhancers defined using ATAC-seq and published ChIP-seq data. We identify candidate target genes for thousands of islet enhancers, and find that enhancer looping is correlated with islet-specific gene exp ...[more]