Ontology highlight
ABSTRACT:
SUBMITTER: Nolan SO
PROVIDER: S-EPMC6506221 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nolan Suzanne O SO Jefferson Taylor S TS Reynolds Conner D CD Smith Gregory D GD Holley Andrew J AJ Hodges Samantha L SL Lugo Joaquin N JN
Neuroreport 20190501 8
The purpose of this investigation was to examine cerebellar levels of several molecular signaling pathways, including PI3K/AKT/mammalian target of rapamycin (mTOR) signaling and markers of neuronal migration, following loss of the phosphatase and tensin homolog (PTEN) gene in a subset of neurons, as well as the accompanying behavior phenotype in mice. Motor coordination and learning were measured by the sticker removal task and the accelerating rotarod. Western blots were conducted on cerebellar ...[more]