Ontology highlight
ABSTRACT:
SUBMITTER: Sandler JE
PROVIDER: S-EPMC6506262 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Sandler Jeremy E JE Irizarry Jihyun J Stepanik Vincent V Dunipace Leslie L Amrhein Henry H Stathopoulos Angelike A
Developmental cell 20181201 6
Rapid mitotic divisions and a fixed transcription rate limit the maximal length of transcripts in early Drosophila embryos. Previous studies suggested that transcription of long genes is initiated but aborted, as early nuclear divisions have short interphases. Here, we identify long genes that are expressed during short nuclear cycles as truncated transcripts. The RNA binding protein Sex-lethal physically associates with transcripts for these genes and is required to support early termination to ...[more]