Ontology highlight
ABSTRACT:
SUBMITTER: Lama D
PROVIDER: S-EPMC6506440 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Lama Dilraj D Quah Soo T ST Verma Chandra S CS Lakshminarayanan Rajamani R Beuerman Roger W RW Lane David P DP Brown Christopher J CJ
Scientific reports 20131213
eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an emerging class of therapeutics that can target protein: protein interactions. We present here molecular dynamics simulations for a set of rationally designed stapled peptides in solution and in complex w ...[more]