Ontology highlight
ABSTRACT:
SUBMITTER: Prakash V
PROVIDER: S-EPMC6506521 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Prakash Varsha V Carson Brittany B BB Feenstra Jennifer M JM Dass Randall A RA Sekyrova Petra P Hoshino Ayuko A Petersen Julian J Guo Yuan Y Parks Matthew M MM Kurylo Chad M CM Batchelder Jake E JE Haller Kristian K Hashimoto Ayako A Rundqivst Helene H Condeelis John S JS Allis C David CD Drygin Denis D Nieto M Angela MA Andäng Michael M Percipalle Piergiorgio P Bergh Jonas J Adameyko Igor I Farrants Ann-Kristin Östlund AÖ Hartman Johan J Lyden David D Pietras Kristian K Blanchard Scott C SC Vincent C Theresa CT
Nature communications 20190508 1
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest. This unexpected EMT feature is independent of species and initiating signal, and is accompanied by release of the repressive nucleolar chromatin remodeling complex (NoRC) from rDNA, together with rec ...[more]