Ontology highlight
ABSTRACT:
SUBMITTER: Chau KF
PROVIDER: S-EPMC5984036 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chau Kevin F KF Shannon Morgan L ML Fame Ryann M RM Fonseca Erin E Mullan Hillary H Johnson Matthew B MB Sendamarai Anoop K AK Springel Mark W MW Laurent Benoit B Lehtinen Maria K MK
eLife 20180510
Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein biosynthetic machinery were strongly downregulated at E10.5. This was matched by decreases in ribosome biogenesis and protein synthesis, together with age-related changes in proteom ...[more]