Immune Modulation in Pediatric Sepsis.
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ABSTRACT:
SUBMITTER: Hall MW
PROVIDER: S-EPMC6506668 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Immune Modulation in Pediatric Sepsis.
Journal of pediatric intensive care 20190102 1
The initial host immune response to sepsis in children is characterized by a proinflammatory surge that can be associated with fever, capillary leak, and organ dysfunction. There is, however, a concurrent anti-inflammatory response that results in hyporesponsiveness of innate and adaptive immune cells. When severe, this response is termed immunoparalysis and is known to be associated with prolonged organ dysfunction, increased risk for nosocomial infection, and death in septic adults and childre ...[more]
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