Ontology highlight
ABSTRACT:
SUBMITTER: Fu X
PROVIDER: S-EPMC6506803 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Fu Xiaorong X Deja Stanisław S Kucejova Blanka B Duarte Joao A G JAG McDonald Jeffrey G JG Burgess Shawn C SC
Analytical chemistry 20190412 9
Intracellular nucleotides and acyl-CoAs are metabolites that are central to the regulation of energy metabolism. They set the cellular energy charge and redox state, act as allosteric regulators, modulate signaling and transcription factors, and thermodynamically activate substrates for oxidation or biosynthesis. Unfortunately, no method exists to simultaneously quantify these biomolecules in tissue extracts. A simple method was developed using ion-pairing reversed-phase high-performance liquid ...[more]