Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC4104812 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Huang Liusheng L Haagensen Janus J Verotta Davide D Lizak Patricia P Aweeka Francesca F Yang Katherine K
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20140514
To support the development of a dynamic in vitro human pharmacokinetic/pharmacodynamic simulation model for biofilm-mediated infections and study stability of meropenem, an LC-MS/MS method for the determination of meropenem in Luria Bertani (LB) media was developed and validated in an API2000 LC-MS/MS system. A partial validation was also performed in M9 media. Sample aliquots of 100μL (or 25μL for M9 media) were mixed with the internal standard (IS) ceftazidime and filtered. The filtrate was di ...[more]