Ontology highlight
ABSTRACT:
SUBMITTER: Corno A
PROVIDER: S-EPMC6507650 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Corno Andrea A Chiroli Elena E Gross Fridolin F Vernieri Claudio C Matafora Vittoria V Maffini Stefano S Cosentino Lagomarsino Marco M Bachi Angela A Ciliberto Andrea A
Life science alliance 20190508 3
Eukaryotic cells treated with microtubule-targeting agents activate the spindle assembly checkpoint to arrest in mitosis and prevent chromosome mis-segregation. A fraction of mitotically arrested cells overcomes the block and proliferates even under persistent checkpoint-activating conditions. Here, we asked what allows proliferation in such unfavourable conditions. We report that yeast cells are delayed in mitosis at each division, implying that their spindle assembly checkpoint remains respons ...[more]