Ontology highlight
ABSTRACT:
SUBMITTER: Milich LM
PROVIDER: S-EPMC6510275 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Milich Lindsay M LM Ryan Christine B CB Lee Jae K JK
Acta neuropathologica 20190330 5
Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, ...[more]