Ontology highlight
ABSTRACT:
SUBMITTER: Choi YJ
PROVIDER: S-EPMC6510728 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Choi Yun Jung YJ Kim Dong Ha DH Yoon Dok Hyun DH Suh Cheolwon C Choi Chang-Min CM Lee Jae Cheol JC Hong Jung Yong JY Rho Jin Kyung JK
Scientific reports 20190510 1
Mantle cell lymphoma (MCL) is typically an aggressive and rare form of non-Hodgkin lymphoma (NHL) with a poor prognosis despite recent advances in immunochemotherapy and targeted therapeutics against NHL. New therapeutic agents are needed for MCL. In this study, we generated a potent inhibitor of cyclin-dependent kinase 7 (CDK7), designated QS1189, and confirmed its anti-cancer effects towards MCL and other lymphomas. QS1189 was highly selective for CDK7 and showed potent anticancer effects in M ...[more]