Synthesis and Molecular Properties of Nerve Agent Reactivator HLo-7 Dimethanesulfonate.
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ABSTRACT: The threat of a deliberate release of chemical nerve agents has underscored the need to continually improve field effective treatments for these types of poisonings. The oxime containing HLö-7 is a potential second-generation therapeutic reactivator. A synthetic process for HLö-7 is detailed with improvements to the DIBAL reduction and ion exchange steps. HLö-7 was visualized for the first time within the active site of human acetylcholinesterase and its relative ex vivo potency confirmed against various nerve agents using a phrenic nerve hemidiaphragm assay.
SUBMITTER: Hsu FL
PROVIDER: S-EPMC6511945 | biostudies-literature |
REPOSITORIES: biostudies-literature
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