Dataset Information

Association of CD11b+ Monocytes and Anti-Vascular Endothelial Growth Factor Injections in Treatment of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.

ABSTRACT:

Importance

CD11b+ immune cells have been implicated in the formation of choroidal neovascularization in experimental studies on animals and disease-association studies on humans. However, the clinical importance of such observations remains unknown.

Objective

To investigate whether the proportion of CD11b+ circulating monocytes is associated with the number of anti-vascular endothelial growth factor (anti-VEGF) injections in neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV).

Design, setting, and participants

These observational cohort studies collected data from January 1, 2010, through December 31, 2013, and from January 1, 2015, through December 31, 2018. Fresh venous blood samples were acquired for flow cytometric immune studies in patients with neovascular AMD or PCV receiving treatment with aflibercept or ranibizumab as needed for 36 months. Patients (n?=?81) without immune diseases were consecutively recruited from a single center in Denmark.

Exposures

Proportion of CD11b+ circulating monocytes.

Main outcomes and measures

The estimation of the number of intravitreal anti-VEGF injections given at 12, 24, and 36 months by the proportion of CD11b+ circulating monocytes and the correlation between these values. The angiogenic role of CD11b+ circulating monocytes was further evaluated by investigating the expression of the known proangiogenic receptor CCR2.

Results

Eighty-one patients were included in the analysis (54% women; mean [SD] age, 76 [7] years). The proportion of CD11b+ monocytes at baseline positively estimated the future number of anti-VEGF injections at 12 (??=?0.77; 95% CI, 0.35-0.93; P?=?.004), 24 (??=?0.82; 95% CI, 0.44-0.95; P?=?.002), and 36 (??=?0.78; 95% CI, 0.34-0.94; P?=?.005) months. This association was also found retrospectively in a larger sample of patients with neovascular AMD at 12 (??=?0.46; 95% CI, 0.16-0.68; P?=?.004), 24 (??=?0.49; 95% CI, 0.20-0.70; P?=?.002), and 36 (??=?0.65; 95% CI, 0.41-0.80; P?Conclusions and relevanceResults of this study demonstrated that the proportion of circulating CD11b+ monocytes estimated and correlated with the number of anti-VEGF injections in patients with neovascular AMD and PCV. Additional longitudinal studies are needed to determine whether these findings have clinical relevance to influence treatment algorithms or provide novel targets for medical therapy.

SUBMITTER: Subhi Y

PROVIDER: S-EPMC6512268 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of CD11b+ Monocytes and Anti-Vascular Endothelial Growth Factor Injections in Treatment of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.

Subhi Yousif Y Krogh Nielsen Marie M Molbech Christopher Rue CR Krüger Falk Mads M Singh Amardeep A Hviid Thomas Vauvert Faurschou TVF Nissen Mogens Holst MH Sørensen Torben Lykke TL

JAMA ophthalmology 20190501 5

<h4>Importance</h4>CD11b+ immune cells have been implicated in the formation of choroidal neovascularization in experimental studies on animals and disease-association studies on humans. However, the clinical importance of such observations remains unknown.<h4>Objective</h4>To investigate whether the proportion of CD11b+ circulating monocytes is associated with the number of anti-vascular endothelial growth factor (anti-VEGF) injections in neovascular age-related macular degeneration (AMD) and p ...[more]

PMID: 30844038

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Dataset Information

Association of CD11b+ Monocytes and Anti-Vascular Endothelial Growth Factor Injections in Treatment of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.

Importance

Objective

Design, setting, and participants

Exposures

Main outcomes and measures

Results

Publications

Association of CD11b+ Monocytes and Anti-Vascular Endothelial Growth Factor Injections in Treatment of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.

Similar Datasets

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