Ontology highlight
ABSTRACT:
SUBMITTER: Tomar D
PROVIDER: S-EPMC6512325 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Tomar Dhanendra D Jaña Fabián F Dong Zhiwei Z Quinn William J WJ Jadiya Pooja P Breves Sarah L SL Daw Cassidy C CC Srikantan Subramanya S Shanmughapriya Santhanam S Nemani Neeharika N Carvalho Edmund E Tripathi Aparna A Worth Alison M AM Zhang Xueqian X Razmpour Roshanak R Seelam Ajay A Rhode Stephen S Mehta Anuj V AV Murray Michael M Slade Daniel D Ramirez Servio H SH Mishra Prashant P Gerhard Glenn S GS Caplan Jeffrey J Norton Luke L Sharma Kumar K Rajan Sudarsan S Balciunas Darius D Wijesinghe Dayanjan S DS Ahima Rexford S RS Baur Joseph A JA Madesh Muniswamy M
Cell reports 20190301 13
Mitochondrial Ca<sup>2+</sup> uniporter (MCU)-mediated Ca<sup>2+</sup> uptake promotes the buildup of reducing equivalents that fuel oxidative phosphorylation for cellular metabolism. Although MCU modulates mitochondrial bioenergetics, its function in energy homeostasis in vivo remains elusive. Here we demonstrate that deletion of the Mcu gene in mouse liver (MCU<sup>Δhep</sup>) and in Danio rerio by CRISPR/Cas9 inhibits mitochondrial Ca<sup>2+</sup> (<sub>m</sub>Ca<sup>2+</sup>) uptake, delays ...[more]