Ontology highlight
ABSTRACT:
SUBMITTER: Mallilankaraman K
PROVIDER: S-EPMC3486697 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Mallilankaraman Karthik K Doonan Patrick P Cárdenas César C Chandramoorthy Harish C HC Müller Marioly M Miller Russell R Hoffman Nicholas E NE Gandhirajan Rajesh Kumar RK Molgó Jordi J Birnbaum Morris J MJ Rothberg Brad S BS Mak Don-On Daniel DO Foskett J Kevin JK Madesh Muniswamy M
Cell 20121001 3
Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner membrane (ΔΨ(m)) generated by proton pumping by the respiratory chain. Mitochondrial matrix Ca(2+) concentration is maintained five to six orders of magnitude lower than its equilibrium level, but the molecular mechanisms for how this is achieved are not clear. Here, we demonstrate that the mitochondrial protein ...[more]