Ontology highlight
ABSTRACT:
SUBMITTER: Kun Z
PROVIDER: S-EPMC6512748 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kun Zhang Z Xin Gao G Tao Wang W Chenglong Zhao Z Dongsheng Wang W Liang Tang T Tielong Liu L Jianru Xiao X
Journal of bone oncology 20190429
Epidermal growth factor-like repeats and discoidin I like domain 3 (EDIL3) is an integrin ligand which is implicated in bone metabolism and bone marrow myelopoiesis. Recently, myeloid derived suppressor cells (MDSCs) as osteoclast progenitor have been demonstrated in several kinds of cancers including breast cancer. In this paper we explored the association between tumor derived EDIL3 and MDSCs in a murine breast cancer model. Knockdown of EDIL3 in MDA-MB-231 breast cancer cells inhibited the ex ...[more]