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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes.

ABSTRACT: The identification in a patient of 1 of the 50 variants in the RYR1 or CACNA1S genes reviewed here should lead to a presumption of malignant hyperthermia susceptibility (MHS). MHS can lead to life-threatening reactions to potent volatile anesthetic agents or succinylcholine. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of these agents in patients with these RYR1 or CACNA1S variants (updates at https://cpicpgx.org/guidelines and www.pharmgkb.org).

SUBMITTER: Gonsalves SG

PROVIDER: S-EPMC6513720 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes.

Gonsalves Stephen G SG Dirksen Robert T RT Sangkuhl Katrin K Pulk Rebecca R Alvarellos Maria M Vo Teresa T Hikino Keiko K Roden Dan D Klein Teri E TE Poler S Mark SM Patel Sephalie S Caudle Kelly E KE Gordon Ronald R Brandom Barbara B Biesecker Leslie G LG

Clinical pharmacology and therapeutics 20190124 6

The identification in a patient of 1 of the 50 variants in the RYR1 or CACNA1S genes reviewed here should lead to a presumption of malignant hyperthermia susceptibility (MHS). MHS can lead to life-threatening reactions to potent volatile anesthetic agents or succinylcholine. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of these agents in patients with these RYR1 or CACNA1S variants (updates at https://cpicpgx.org/guidel ...[more]

PMID: 30499100

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