Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6513721 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wang Jian J Kumar Shaun S SS Sherwin Catherine M CM Ward Robert R Baer Gerri G Burckart Gilbert J GJ Wang Yaning Y Yao Lynne P LP
Clinical pharmacology and therapeutics 20190210 6
The objective of this study was to evaluate the predictive performance of population models to predict renal clearance in newborns and infants. Pharmacokinetic (PK) data from eight drugs in 788 newborns and infants were used to evaluate the predictive performance of the population models based on postmenstrual age (PMA), postnatal age, gestational age, and body weight. For the PMA model, the average fold error for clearance (CL)<sub>predicted</sub> /CL<sub>observed</sub> was within a twofold ran ...[more]