Ontology highlight
ABSTRACT:
SUBMITTER: Kim JM
PROVIDER: S-EPMC6514701 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kim Jung-Min JM Yang Yeon-Suk YS Park Kwang Hwan KH Oh Hwanhee H Greenblatt Matthew B MB Shim Jae-Hyuck JH
International journal of molecular sciences 20190412 8
Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that function as key signal transducers of a wide spectrum of extracellular stimuli, including growth factors and pro-inflammatory cytokines. Dysregulation of the extracellular signal-regulated kinase (ERK) MAPK pathway is associated with human skeletal abnormalities including Noonan syndrome, neurofibromatosis type 1, and cardiofaciocutaneous syndrome. Here, we demonstrate that ERK activation in osteoprogenitors is requir ...[more]