Unknown

Dataset Information

0

Specific functions for ERK/MAPK signaling during PNS development.


ABSTRACT: We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.

SUBMITTER: Newbern JM 

PROVIDER: S-EPMC3060558 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications


We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted diffe  ...[more]

Similar Datasets

2010-10-16 | E-GEOD-24730 | biostudies-arrayexpress
2010-10-16 | GSE24730 | GEO
| S-EPMC5566864 | biostudies-literature
2014-09-02 | E-GEOD-51643 | biostudies-arrayexpress
2014-09-02 | GSE51643 | GEO
| S-EPMC1761141 | biostudies-literature
| S-EPMC4758957 | biostudies-literature
| S-EPMC8234271 | biostudies-literature
2013-12-01 | E-GEOD-33537 | biostudies-arrayexpress
| S-EPMC4514964 | biostudies-literature