Ontology highlight
ABSTRACT:
SUBMITTER: Newbern JM
PROVIDER: S-EPMC3060558 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Newbern Jason M JM Li Xiaoyan X Shoemaker Sarah E SE Zhou Jiang J Zhong Jian J Wu Yaohong Y Bonder Daniel D Hollenback Steven S Coppola Giovanni G Geschwind Daniel H DH Landreth Gary E GE Snider William D WD
Neuron 20110101 1
We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted diffe ...[more]