Ontology highlight
ABSTRACT:
SUBMITTER: Stylianou N
PROVIDER: S-EPMC6514858 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Stylianou Nataly N Lehman Melanie L ML Wang Chenwei C Fard Atefeh Taherian AT Rockstroh Anja A Fazli Ladan L Jovanovic Lidija L Ward Micheal M Sadowski Martin C MC Kashyap Abhishek S AS Buttyan Ralph R Gleave Martin E ME Westbrook Thomas F TF Williams Elizabeth D ED Gunter Jennifer H JH Nelson Colleen C CC Hollier Brett G BG
Oncogene 20180907 7
The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial-mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcriptional investigations using reversible models of EMT, revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC). From this enrichment, a metastasis-derived ...[more]