A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.
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ABSTRACT: The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states is considered to be critical in metastatic processes, cancer progression, and treatment resistance. To investigate a transient epithelial-mesenchymal transition (EMT) in prostate adenocarcinoma, LNCaP cells with inducible and reversible expression of SNAI1 or SNAI2 were generated. Cells were treated with doxycycline to induce a SNAI1- or SNAI2-mediated EMT for 5 days and then subsequently removed for 3, 5, and 20 days to allow for MET. LNCaP-iGFP cells were also generated for control purposes and were subjected to the same treatment regime.
ORGANISM(S): Homo sapiens
PROVIDER: GSE80042 | GEO | 2018/09/11
REPOSITORIES: GEO
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