Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.
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ABSTRACT:
SUBMITTER: Walaszczyk A
PROVIDER: S-EPMC6516151 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.
Walaszczyk Anna A Dookun Emily E Redgrave Rachael R Tual-Chalot Simon S Victorelli Stella S Spyridopoulos Ioakim I Owens Andrew A Arthur Helen M HM Passos João F JF Richardson Gavin D GD
Aging cell 20190328 3
Cardiovascular disease is the leading cause of death in individuals over 60 years old. Aging is associated with an increased prevalence of coronary artery disease and a poorer prognosis following acute myocardial infarction (MI). With age, senescent cells accumulate in tissues, including the heart, and contribute to age-related pathologies. However, the role of senescence in recovery following MI has not been investigated. In this study, we demonstrate that treatment of aged mice with the senoly ...[more]
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