Ontology highlight
ABSTRACT:
SUBMITTER: Dookun E
PROVIDER: S-EPMC7576252 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Dookun Emily E Walaszczyk Anna A Redgrave Rachael R Palmowski Pawel P Tual-Chalot Simon S Suwana Averina A Chapman James J Jirkovsky Eduard E Donastorg Sosa Leticia L Gill Eleanor E Yausep Oliver E OE Santin Yohan Y Mialet-Perez Jeanne J Andrew Owens W W Grieve David D Spyridopoulos Ioakim I Taggart Michael M Arthur Helen M HM Passos João F JF Richardson Gavin D GD
Aging cell 20200929 10
A key component of cardiac ischemia-reperfusion injury (IRI) is the increased generation of reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study, we hypothesized that oxidative stress, due to ischemia-reperfusion, induces senescence which contributes to the pathophysiology of cardiac IRI. We demonstrate that IRI induces cellular senescence in both cardiomyocytes and interstitial cell populatio ...[more]