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Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.

ABSTRACT:

SUBMITTER: Bulsara VM

PROVIDER: S-EPMC6517307 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.

Bulsara Vishal M VM Worthington Helen V HV Glenny Anne-Marie AM Clarkson Janet E JE Conway David I DI Macluskey Michaelina M

The Cochrane database of systematic reviews 20181224

<h4>Background</h4>Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early-stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of pe ...[more]

PMID: 30582609

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Project description:BackgroundOral and oropharyngeal cancers are considered important public health problems worldwide. This study aims to analyze the association between late diagnosis of oral and oropharyngeal cancers in Brazil and the contextual indicators of socioeconomic variables and coverage of Primary Health Care (PHC), and to assess the temporal trend of late diagnosis.MethodsIn this cross-sectional observational study, secondary data were evaluated with a time series analysis. All Brazilian cities that reported at least one case of oral and oropharyngeal cancers each year in the period between 2000 and 2013 were included; and the staging was analyzed by calculating the ratio risk for late diagnosis for each municipality. The association between staging and socioeconomic variables and offer of PHC was calculated using multiple linear regression. The time trend of the risk ratio for late-stage diagnosis was calculated using the Prais-Winsten method.ResultsOne hundred and sixty Brazilian municipalities had at least one annual case of oral and oropharyngeal cancers notified to the INCA hospital system between 2000 and 2013. The adjusted model showed that the higher the Gini value (greater social inequality) and the lower the HDI value (less human development) was, the higher was the number of tumors diagnosed at a late stage, considering the size of the tumor. A greater risk for late diagnosis was identified, as early as at the stage of lymph node involvement, when there was a higher level of social inequality and lower level of coverage by Oral Health Teams (OHT) in PHC. The greater the social inequality, the greater was the risk of late diagnosis, as early as in the stage of metastasis.ConclusionsWe concluded that, during the evaluated period, there was an increase in the number of cases diagnosed at the most advanced stage. Furthermore, there was association between higher levels of social inequality and an increase in the proportion of late diagnosis of oral and oropharyngeal cancers. In addition, the inclusion of Oral Health Teams in Primary Health Care promoted the early diagnosis of these types of cancers.

Dataset Information

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.

Publications

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.

Similar Datasets

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