Dataset Information

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program.

ABSTRACT:

Background

To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC).

Methods

We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012.

Results

The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6?weeks compared with that shorter than 3?weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6?weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P?ConclusionsTreatment delay longer than 6?weeks for OSCCs detected via a population-based screening program had unfavorable survival.

SUBMITTER: Su WW

PROVIDER: S-EPMC7820997 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program.

Su William Wang-Yu WW Lee Yi-Huah YH Yen Amy Ming-Fang AM Chen Sam Li-Sheng SL Hsu Chen-Yang CY Chiu Sherry Yueh-Hsia SY Fann Jean Ching-Yuan JC Lee Yi-Chia YC Chiu Han-Mo HM Hsiao Shu-Chun SC Hsu Tsui-Hsia TH Chen Hsiu-Hsi HH

Head & neck 20201013 2

<h4>Background</h4>To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC).<h4>Methods</h4>We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012.<h4>Results</h4>The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. Th ...[more]

PMID: 33047420

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Project description:BackgroundOral and oropharyngeal cancers are considered important public health problems worldwide. This study aims to analyze the association between late diagnosis of oral and oropharyngeal cancers in Brazil and the contextual indicators of socioeconomic variables and coverage of Primary Health Care (PHC), and to assess the temporal trend of late diagnosis.MethodsIn this cross-sectional observational study, secondary data were evaluated with a time series analysis. All Brazilian cities that reported at least one case of oral and oropharyngeal cancers each year in the period between 2000 and 2013 were included; and the staging was analyzed by calculating the ratio risk for late diagnosis for each municipality. The association between staging and socioeconomic variables and offer of PHC was calculated using multiple linear regression. The time trend of the risk ratio for late-stage diagnosis was calculated using the Prais-Winsten method.ResultsOne hundred and sixty Brazilian municipalities had at least one annual case of oral and oropharyngeal cancers notified to the INCA hospital system between 2000 and 2013. The adjusted model showed that the higher the Gini value (greater social inequality) and the lower the HDI value (less human development) was, the higher was the number of tumors diagnosed at a late stage, considering the size of the tumor. A greater risk for late diagnosis was identified, as early as at the stage of lymph node involvement, when there was a higher level of social inequality and lower level of coverage by Oral Health Teams (OHT) in PHC. The greater the social inequality, the greater was the risk of late diagnosis, as early as in the stage of metastasis.ConclusionsWe concluded that, during the evaluated period, there was an increase in the number of cases diagnosed at the most advanced stage. Furthermore, there was association between higher levels of social inequality and an increase in the proportion of late diagnosis of oral and oropharyngeal cancers. In addition, the inclusion of Oral Health Teams in Primary Health Care promoted the early diagnosis of these types of cancers.

Dataset Information

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program.

Background

Methods

Results

Publications

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program.

Similar Datasets

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