Serum magnesium and the risk of prediabetes: a population-based cohort study.

ABSTRACT:

Aims/hypothesis

Previous studies have found an association between serum magnesium and incident diabetes; however, this association may be due to reverse causation, whereby diabetes may induce urinary magnesium loss. In contrast, in prediabetes (defined as impaired fasting glucose), serum glucose levels are below the threshold for urinary magnesium wasting and, hence, unlikely to influence serum magnesium levels. Thus, to study the directionality of the association between serum magnesium levels and diabetes, we investigated its association with prediabetes. We also investigated whether magnesium-regulating genes influence diabetes risk through serum magnesium levels. Additionally, we quantified the effect of insulin resistance in the association between serum magnesium levels and

SUBMITTER: Kieboom BCT 

PROVIDER: S-EPMC6518103 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature