Ontology highlight
ABSTRACT:
SUBMITTER: Steen HC
PROVIDER: S-EPMC6518330 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Steen Håkan C HC Kotredes Kevin P KP Nogusa Shoko S Harris Michele Y MY Balachandran Siddharth S Gamero Ana M AM
Journal of cell science 20161019 22
Serine phosphorylation of STAT proteins is an important post-translational modification event that, in addition to tyrosine phosphorylation, is required for strong transcriptional activity. However, we recently showed that phosphorylation of STAT2 on S287 induced by type I interferons (IFN-α and IFN-β), evoked the opposite effect. S287-STAT2 phosphorylation inhibited the biological effects of IFN-α. We now report the identification and characterization of S734 on the C-terminal transactivation d ...[more]