Dataset Information

Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction.

ABSTRACT:

Aims/hypothesis

Women with a history of gestational diabetes mellitus (GDM) have raised liver triacylglycerol. Restriction of energy intake in type 2 diabetes can normalise glucose control and liver triacylglycerol concentration but it is not known whether similar benefits could be achieved in GDM. The aim of this work was to examine liver triacylglycerol accumulation in women with GDM and the effect of modest energy restriction.

Methods

Sixteen women with GDM followed a 4 week diet (5 MJ [1200 kcal]/day). Liver triacylglycerol, before and after diet and postpartum, was measured by magnetic resonance. Insulin secretion and sensitivity were assessed before and after diet. Twenty-six women who underwent standard antenatal care for GDM (matched for age, BMI, parity and ethnicity) were used as a comparator group.

Results

Fourteen women, who completed the study, achieved a weight loss of 1.6?±?1.7 kg over the 4 week dietary period. Mean weight change was -0.4 kg/week in the study group vs +0.3 kg/week in the comparator group (p?=?0.002). Liver triacylglycerol level was normal but decreased following diet (3.7% [interquartile range, IQR 1.2-6.1%] vs 1.8% [IQR 0.7-3.1%], p?=?0.004). There was no change in insulin sensitivity or production. Insulin was required in six comparator women vs none in the study group (eight vs two required metformin). Blood glucose control was similar for both groups. The hypo-energetic diet was well accepted.

Conclusions/interpretation

Liver triacylglycerol in women with GDM was not elevated, unlike observations in non-pregnant women with a history of GDM. A 4 week hypo-energetic diet resulted in weight loss, reduced liver triacylglycerol and minimised pharmacotherapy. The underlying pathophysiology of glucose metabolism appeared unchanged.

SUBMITTER: Hodson K

PROVIDER: S-EPMC6518369 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction.

Hodson Kenneth K Dalla Man Chiara C Smith Fiona E FE Barnes Alison A McParlin Catherine C Cobelli Claudio C Robson Stephen C SC Araújo-Soares Vera V Taylor Roy R

Diabetologia 20161105 2

<h4>Aims/hypothesis</h4>Women with a history of gestational diabetes mellitus (GDM) have raised liver triacylglycerol. Restriction of energy intake in type 2 diabetes can normalise glucose control and liver triacylglycerol concentration but it is not known whether similar benefits could be achieved in GDM. The aim of this work was to examine liver triacylglycerol accumulation in women with GDM and the effect of modest energy restriction.<h4>Methods</h4>Sixteen women with GDM followed a 4 week di ...[more]

PMID: 27817155

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Dataset Information

Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction.

Aims/hypothesis

Methods

Results

Conclusions/interpretation

Publications

Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction.

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