Ontology highlight
ABSTRACT:
SUBMITTER: Leoutsakos JS
PROVIDER: S-EPMC6518401 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Leoutsakos Jeannie-Marie S JS Yan Haijuan H Anderson William S WS Asaad Wael F WF Baltuch Gordon G Burke Anna A Chakravarty M Mallar MM Drake Kristen E KE Foote Kelly D KD Fosdick Lisa L Giacobbe Peter P Mari Zoltan Z McAndrews Mary Pat MP Munro Cynthia A CA Oh Esther S ES Okun Michael S MS Pendergrass Jo Cara JC Ponce Francisco A FA Rosenberg Paul B PB Sabbagh Marwan N MN Salloway Stephen S Tang-Wai David F DF Targum Steven D SD Wolk David D Lozano Andres M AM Smith Gwenn S GS Lyketsos Constantine G CG
Journal of Alzheimer's disease : JAD 20180101 2
<h4>Background</h4>Given recent challenges in developing new treatments for Alzheimer dementia (AD), it is vital to explore alternate treatment targets, such as neuromodulation for circuit dysfunction. We previously reported an exploratory Phase IIb double-blind trial of deep brain stimulation targeting the fornix (DBS-f) in mild AD (the ADvance trial). We reported safety but no clinical benefits of DBS-f versus the delayed-on (sham) treatment in 42 participants after one year. However, secondar ...[more]