Ontology highlight
ABSTRACT:
SUBMITTER: Wright GEB
PROVIDER: S-EPMC6519044 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wright Galen E B GEB Amstutz Ursula U Drögemöller Britt I BI Shih Joanne J Rassekh Shahrad R SR Hayden Michael R MR Carleton Bruce C BC Ross Colin J D CJD
Clinical pharmacology and therapeutics 20180817 2
Vincristine is an effective chemotherapeutic drug for various cancers, including acute lymphoblastic leukemia (ALL). Unfortunately, clinical utility is restricted by dose-limiting vincristine-induced peripheral neuropathies (VIPN). We sought to determine the association of VIPN with a recently identified risk variant, CEP72 rs924607, and drug absorption, distribution, metabolism, and excretion (ADME) gene variants in pediatric ALL. This was followed by a meta-analysis of pharmacogenomic data fro ...[more]