Ontology highlight
ABSTRACT:
SUBMITTER: Eshleman SH
PROVIDER: S-EPMC6519133 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Eshleman Susan H SH Laeyendecker Oliver O Kammers Kai K Chen Athena A Sivay Mariya V MV Kottapalli Sanjay S Sie Brandon M BM Yuan Tiezheng T Monaco Daniel R DR Mohan Divya D Wansley Daniel D Kula Tomasz T Morrison Charles C Elledge Stephen J SJ Brookmeyer Ron R Ruczinski Ingo I Larman H Benjamin HB
Cell reports 20190401 5
This study evaluates HIV antibody responses and their evolution during the course of HIV infection. A phage display system is used to characterize antibody binding to >3,300 HIV peptides in 57 adults with early- to late-stage infection. We find that the number of unique epitopes targeted ("antibody breadth") increases early in infection and then stabilizes or declines. A decline in antibody breadth 9 months to 2 years after infection is associated with subsequent antiretroviral treatment (ART) i ...[more]