Ontology highlight
ABSTRACT:
SUBMITTER: de la Pena AH
PROVIDER: S-EPMC6519459 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
de la Peña Andres H AH Goodall Ellen A EA Gates Stephanie N SN Lander Gabriel C GC Martin Andreas A
Science (New York, N.Y.) 20181011 6418
The 26<i>S</i> proteasome is the primary eukaryotic degradation machine and thus is critically involved in numerous cellular processes. The heterohexameric adenosine triphosphatase (ATPase) motor of the proteasome unfolds and translocates targeted protein substrates into the open gate of a proteolytic core while a proteasomal deubiquitinase concomitantly removes substrate-attached ubiquitin chains. However, the mechanisms by which ATP hydrolysis drives the conformational changes responsible for ...[more]