Competitive Tuning Among Ca2+/Calmodulin-Dependent Proteins: Analysis of in silico Model Robustness and Parameter Variability.
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ABSTRACT:
SUBMITTER: Pharris MC
PROVIDER: S-EPMC6519966 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Competitive Tuning Among Ca<sup>2+</sup>/Calmodulin-Dependent Proteins: Analysis of <i>in silico</i> Model Robustness and Parameter Variability.
Pharris Matthew C MC Patel Neal M NM Kinzer-Ursem Tamara L TL
Cellular and molecular bioengineering 20180906 5
<h4>Introduction</h4>Calcium/Calmodulin-dependent (Ca<sup>2+</sup>/CaM-dependent) regulation of protein signaling has long been recognized for its importance in a number of physiological contexts. Found in almost all eukaryotic cells, Ca<sup>2+</sup>/CaM-dependent signaling participates in muscle development, immune responses, cardiac myocyte function and regulation of neuronal connectivity. In excitatory neurons, dynamic changes in the strength of synaptic connections, known as synaptic plastic ...[more]
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