Quantifying T ₂ relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.

ABSTRACT: The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T ₂ relaxation time changes in ischaemic brain such that T ₂ in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T ₂ in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T ₂ on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We s

SUBMITTER: Damion RA 

PROVIDER: S-EPMC6520250 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature