Ontology highlight
ABSTRACT:
SUBMITTER: Paul A
PROVIDER: S-EPMC6520660 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in molecular neuroscience 20190509
SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in <i>SYNGAP1</i> (<i>SYNGAP1</i> <sup>-/+</sup>) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse model of <i>Syngap1</i> <sup>-/+</sup>. However, the molecular mechanism behind the same is unclear. Here, we report the reduced expression of a known tra ...[more]