Ontology highlight
ABSTRACT:
SUBMITTER: Ni S
PROVIDER: S-EPMC6904668 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ni Shuangfei S Luo Zixiang Z Jiang Liyuan L Guo Zhu Z Li Ping P Xu Xiang X Cao Yong Y Duan Chunyue C Wu Tianding T Li Chengjun C Lu Hongbin H Hu Jianzhong J
Molecular therapy : the journal of the American Society of Gene Therapy 20190822 12
The regeneration of the blood vessel system post spinal cord injury (SCI) is essential for the repair of neurological function. As a significant means to regulate gene expression, epigenetic regulation of angiogenesis in SCI is still largely unknown. Here, we found that Ubiquitously Transcribed tetratricopeptide repeat on chromosome X (UTX), the histone H3K27 demethylase, increased significantly in endothelial cells post SCI. Knockdown of UTX can promote the migration and tube formation of endot ...[more]