Ontology highlight
ABSTRACT:
SUBMITTER: Almeida M
PROVIDER: S-EPMC6522364 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Almeida Mafalda M Pintacuda Greta G Masui Osamu O Koseki Yoko Y Gdula Michal M Cerase Andrea A Brown David D Mould Arne A Innocent Cassandravictoria C Nakayama Manabu M Schermelleh Lothar L Nesterova Tatyana B TB Koseki Haruhiko H Brockdorff Neil N
Science (New York, N.Y.) 20170601 6342
Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long noncoding RNAs. Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression. PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 me ...[more]